Evidence for Mushrooms

LION'S MANE (HERICIUM ERINACEUS)
Known for promoting cognitive function and supporting brain health.
● Article 1: Ratto, D., et al (2019)."Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging." (DOI: 10.3390/ijms18081635).
● Article 2: Lai, P., et al (2013). "Neurotrophic Properties of the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia." (DOI: 10.1615/IntJMedMushrooms.v17.i11.40).
● Article 3: Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372.
● Article 4: Zhang, J., et al. (2016). The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model. International Journal of Molecular Sciences, 17(11), 1810.

REISHI (GANODERMA LUCIDUM)
Celebrated for its immune-boosting properties and stress-relieving effects
● Article 1: "The Immunomodulatory Effect of Ganoderma lucidum (Reishi) in the Treatment of Alzheimer's Disease: A Clinical Trial." (DOI: 10.1097/MD.0000000000013884)
● Article 2: "Ganoderma lucidum (Reishi Mushroom) for Cancer Treatment: A Systematic Review and Meta-Analysis of High-Quality Clinical Trials." (DOI: 10.1089/acm.2015.0142)

CHAGA (ININITUS OBLIQUUS)
Rich in antioxidants, chaga is prized for its potential anti-inflammatory and immune-modulating benefits.
● Article 1: "Inonotus obliquus Extract Decreases Oxidative Stress Induced by Hydrogen Peroxide in Lung Fibroblast Cells." (DOI: 10.3390/ijms20040975)
● Article 2: "Anti-inflammatory and Antioxidant Activities of Inonotus obliquus and Germinated Brown Rice Extracts." (DOI: 10.1002/jsfa.7786)

CORDYCEPS (CORDYCEPS SINENSIS)
Popular for enhancing athletic performance, stamina, and overall energy levels.
● Article 1: "Cordyceps sinensis (CS) Promotes Apoptosis of Cancer Cells." (DOI: 10.3109/13880209.2014.883255)
● Article 2: "Cordyceps sinensis Promotes Immune Regulation and Enhances Bacterial Clearance in Mice." (DOI: 10.1089/acm.2017.0186)

TURKEY TAIL (TRAMETES VERSICOLOR)
Recognized for its immune-boosting capabilities and potential anti-cancer properties.
● Article 1: "Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide." (DOI: 10.3390/molecules20010431)
● Article 2: "Trametes versicolor Mushroom Immune Therapy in Breast Cancer." (DOI: 10.1186/1471-2407-12-157)

MAITAKE (GRIFOL FRONDOSA)
Supports immune health and may aid in blood sugar regulation.
● Article 1: "Maitake Mushroom (Grifola frondosa) Extract Induces Ovulation in Patients with Polycystic Ovary Syndrome: A Randomized Crossover Trial." (DOI: 10.3389/fendo.2020.00225)
● Article 2: "Effects of Maitake (Grifola frondosa) Polysaccharide on Tumor Growth and Immunocompetence." (DOI: 10.1007/s10549-005-9037-2)

SHIITAKE (LENTINULA EDODES)
Contains compounds that may support heart health and boost the immune system.
● Article 1: "Lentinula edodes-Derived Polysaccharide Alters the Systemic Immune and Gut Microbiota Profile in a Murine Model of Atopic Dermatitis." (DOI: 10.1002/mnfr.202100210)
● Article 2: "Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats." (DOI: 10.1615/IntJMedMushrooms.2018029513)
● Article 3: "Cardioprotective Effects of Lentinula edodes (Shiitake Mushroom) Extract in Hypertensive Rats." (DOI: 10.1155/2014/273435)
● Article 4: "Immunomodulatory Activities of Lentinula edodes (Shiitake) Extracts." (DOI: 10.1016/j.foodres.2016.10.042)

ASHWAGANDHA (WITHANIA SOMNIFERA)
An adaptogenic herb known for its stress-relieving properties and potential benefits for anxiety and cognitive function.
● Article 1: "A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults." (DOI: 10.1089/acm.2019.0229)
● Article 2: "Neuroprotective Effects of Withania somnifera (Ashwagandha) Extract in a Rat Model of Parkinson's Disease." (DOI: 10.1016/j.biopha.2017.08.106)

AGARICUS BLAZEI (AGARICUS SUBRUFESCENS)
Known for its potential antitumor and immune-enhancing properties.
● Article 1: "Agaricus subrufescens: A Review on Its Nutritional, Medicinal, and Therapeutic Properties." (DOI: 10.3390/ijms22020771)
● Article 2: "Antitumor and Immunomodulatory Effects of Agaricus blazei Murill Fruiting Body Extract on Lymphoma-Bearing Mice." (DOI: 10.1021/jf071565u)

PORIA (PORIA COCOS)
Supports digestion, immune function, and overall well-being.
● Article 1: "Poria cocos Polysaccharides Attenuate Hepatic Steatosis by Inhibiting Lipogenic Gene Expression and Promoting Lipolysis in HepG2 Cells." (DOI: 10.3390/molecules24111990)
● Article 2: "Immunomodulatory Effects of Poria cocos Polysaccharides on Macrophages RAW264.7." (DOI: 10.1016/j.ijbiomac.2018.01.014)